淋巴细胞异常怎么治疗好：血液笔谈 淋巴细胞 想说爱你不容易

淋巴细胞异常怎么治疗好：血液笔谈 淋巴细胞 想说爱你不容易02B 图：伴有多克隆淋巴细胞增多症的重度吸烟者外周血中具有代表性的双核淋巴细胞。These mature lymphocytes are increased markedly in number. They are indicative of chronic lymphocytic leukemia. 成熟的淋巴细胞在数量上明显增加，提示慢性淋巴细胞性白血病.A 图：免疫表型显示为T淋巴细胞，CD4 或CD8 。

A normal mature lymphocyte is seen on the left compared to a segmented PMN on the right. An RBC is seen to be about 2/3 the size of a normal lymphocyte.

左侧可见一正常的、成熟的淋巴细胞，右侧是与其比较的分叶核嗜中性粒细胞。RBC是正常的淋巴细胞的2/3大小。

They are atypical because they are larger (more cytoplasm) and have nucleoli in their nuclei. The cytoplasm tends to be indented by surrounding RBC's. Such atypical lymphocytes are often associated with infectious mononucleosis.

可见非典型淋巴细胞，之所以称为非典型，是因为体积更大（更多的细胞质）并可见核仁。细胞质因RBC挤压而成锯齿形。多见于感染性单核细胞增多症。

These mature lymphocytes are increased markedly in number. They are indicative of chronic lymphocytic leukemia.

成熟的淋巴细胞在数量上明显增加，提示慢性淋巴细胞性白血病.

A 图：免疫表型显示为T淋巴细胞，CD4 或CD8 。

B 图：伴有多克隆淋巴细胞增多症的重度吸烟者外周血中具有代表性的双核淋巴细胞。

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B细胞

同样先简单回顾一下B淋巴细胞的发育及其抗原表达情况：

B细胞分化分为两个时期：抗原非依赖期和抗原依赖期。非依赖期在骨髓，不受抗体影响，包括：祖B细胞、前B细胞、未成熟B细胞、成熟B细胞（或称naive/初始B细胞）。依赖期为初始B细胞离开骨髓到外周免疫器官的非胸腺依赖区，遇到抗原刺激则分化为浆细胞；没遇到则几周后死亡。