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awr报告详细解读(一文速览2022年ACR会议中狼疮领域的最新资讯)

awr报告详细解读(一文速览2022年ACR会议中狼疮领域的最新资讯)摘要号:2072研究标题:LN患者的类固醇糖尿病:是经典风险因素,还是一种不同类型的糖尿病?彷徨与呐喊:狼疮领域未被满足的临床需求摘要号:0353Steroid-Induced Diabetes in Lupus Nephritis Patients:Classic Risk Factors or a Different Type of Diabetes?

*仅供医学专业人士阅读参考

awr报告详细解读(一文速览2022年ACR会议中狼疮领域的最新资讯)(1)

ACR 2022一周热点研究预告,聚焦狼疮领域前沿进展。

2022年美国风湿病学会(ACR)年会将于11月10日至14日在宾夕法尼亚州费城的宾夕法尼亚会议中心举行——是的,就在明天!这个在世界范围内最负盛名的风湿病学会议就要开幕了!

在每年的ACR年会上,风湿病领域中极具影响力的专家学者、医生、卫生专业人员和科学研究工作者都会齐聚一堂,为大家带来最新、最前沿的风湿病学研究与临床应用信息。对于这个一年一度的学术盛典,您是不是很激动、很期待呢?是否在畅想,今年的ACR年会将带给我们怎样的精彩内容?

awr报告详细解读(一文速览2022年ACR会议中狼疮领域的最新资讯)(2)

贴心如小编,已经提前为你们梳理好会议中狼疮领域的内容精要。各位风湿同仁,快来查收吧!

彷徨与呐喊:狼疮领域未被满足的临床需求

摘要号:0353

Steroid-Induced Diabetes in Lupus Nephritis Patients:Classic Risk Factors or a Different Type of Diabetes?

研究标题:LN患者的类固醇糖尿病:是经典风险因素,还是一种不同类型的糖尿病?

摘要号:2072

Estimating Corticosteroid-Related Morbidity in Lupus Nephritis:The Glucocorticoid Toxicity Index

研究标题:LN皮质类固醇相关的疾病发病率估计:糖皮质激素毒性指数(GTI)

摘要号:0345

Association Between Cumulated Hydroxychloroquine in Systemic Lupus Erythematosus and Development of Cardiac Conduction Alterations:A Multiple Logistic Regression Analysis

研究标题:SLE患者羟氯喹的累积与心脏传导改变的发展之间的关联性:多因素Logistic回归分析

摘要号:1186

The Trajectory of Multimorbidity in Patients with Systemic Lupus Erythematosus in the United States

研究标题:美国系统性红斑狼疮(SLE)患者多种合并症的疾病进程

摘要号:2197

Unmet Need in Systemic Lupus Erythematosus(SLE)Therapy:High Corticosteroid Use and Poor Adherence and Persistence to SLE Treatments in the US

研究标题:SLE治疗需求未得到满足:皮质类固醇的高使用率以及患者的治疗依从性和持续性差(美国)

摘要号:2076

Unfavorable Outcomes Associated with Current Standard of Care in the Management of Patients with Systemic Lupus Erythematosus

研究标题:在当前SLE患者的临床管理中,传统免疫抑制剂与患者的不良结局相关

摘要号:1347

Poor Health-Related Quality of Life in Patients with Lupus Nephritis

研究标题:狼疮肾炎(LN)患者生活质量较差

快速缓解和防止复发的重要性:

The sooner the better;

The longer the better

摘要号:2077

Does Early Complete Remission Preclude Adverse Outcomes in Lupus Nephritis?

研究标题:早期完全缓解能否预防LN的不良结局?

摘要号:2061

Impact of Time to Remission Flares and Exposure to Immunosuppressives on the Development of Advanced Chronic Kidney Disease(Stage IV or Worse)in Lupus Nephritis

研究标题:达到缓解所需时间、复发和免疫抑制剂使用时间对LN患者发生晚期慢性肾脏病的影响

摘要号:1450

Impact of Time to Remission Flares and Time on Immunosuppressives on the Estimated Glomerular Filtration Rate in Lupus Nephritis

研究标题:缓解时间、发作时间以及完全缓解后免疫抑制剂的使用时间对LN患者肾小球滤过率的影响

摘要号:2065

Sustained B Cell Depletion in Lupus Nephritis Patients After Treatment with a B Cell Agent Is Associated with Fewer Disease Flares

研究标题:使用B细胞通路药物治疗后,LN患者持续B细胞耗竭与疾病发作减少有关

摘要号:0347

Real-World Effectiveness of Belimumab in Patients with SLE in the United States

研究标题:贝利尤单抗在美国真实世界中对SLE患者的治疗有效性

摘要号:0351

The Effect of Belimumab to Achieve Low Disease Activity or Remission Based on SLE-DAS in Systemic Lupus Erythematosus:A Single-center Retrospective Study

研究标题:贝利尤单抗治疗SLE实现低疾病活动度或缓解(基于SLEDAS评分)的效果:一项单中心回顾性研究

小心“狼”的杀手锏——器官损害

摘要号:0319

Factors Associated with Worsening Interstitial Fibrosis/Tubular Atrophy in Lupus Nephritis Patients Undergoing Repeat Kidney Biopsy

研究标题:与接受重复肾活检的LN患者间质纤维化恶化/肾小管萎缩相关的因素

摘要号:0352

The Effect of Belimumab(BEL) on Kidney Outcomes in SLE:Results of a Large Integrated Analysis

研究标题:贝利尤单抗治疗对SLE患者肾脏预后的影响:一项大型综合分析的结果

摘要号:0979

Belimumab Effects on Skin in Patients with Systemic Lupus Erythematosus:A Pooled Post Hoc Analysis of Five Phase 3 Randomized Placebo-Controlled Clinical Trials

研究标题:贝利尤单抗治疗对SLE患者皮肤病变的影响:5个3期随机安慰剂对照临床试验的汇总分析

摘要号:0348

Significant Improvement in Cutaneous Lupus Erythematosus with or Without Systemic Lupus Erythematosus with Belimumab Use–a Systematic Review and Meta-Analysis

研究标题:贝利尤单抗治疗对伴或不伴SLE的皮肤红斑狼疮(CLE)有显著改善:一项系统综述和荟萃分析

摘要号:2088

Achieving Systemic Lupus Erythematosus Disease Control or Low Lupus Disease Activity State Is Associated with Lower Rates of Organ Damage:Results from the Hopkins Lupus Cohort

研究标题:实现SLE疾病控制或低疾病活动状态与较低的器官损伤进展率相关:来自霍普金斯狼疮队列的结果

摘要号:1463

Short-and Long-Term Progression of Kidney Involvement in Systemic Lupus Erythematosus Patients with Low-Grade Proteinuria

研究标题:伴轻度蛋白尿的SLE患者肾脏受累的短期及长期进展

常规治疗虽重要,但也有局限性!——治疗用药莫忘“安全”二字

摘要号:0349

Comparative Risks of Infection with Belimumab versus Oral Immunosuppressants in Patients with Non-Renal Systemic Lupus Erythematosus

研究标题:非肾脏受累SLE患者使用贝利尤单抗与口服免疫抑制剂的感染风险比较

摘要号:0367

Comparative Risk of COVID-19 Among Patients with Systemic Lupus Erythematosus According to Immunosuppressant Use

研究标题:比较不同免疫抑制剂的使用情况SLE患者的感染COVID-19的风险

摘要号:0961

The Use of Belimumab Before and During Pregnancy in Patients with Systemic Lupus Erythematosus:An Italian Multicenter Case-series

研究标题:贝利尤单抗在SLE患者妊娠前和妊娠期间的应用:意大利多中心病例系列

临床与病理密切配合,这些评估指标究竟反映了什么?

摘要号:0634

Total Interstitial Inflammation Predicts Chronic Kidney Disease Progression in Patients with Lupus Nephritis

研究标题:LN患者的总体间质性炎症可预测慢性肾脏疾病的进展

摘要号:0655

Proteomic Analysis of Histological Lesions Lupus Nephritis Identifies an Inflammatory Signature of Fibrous Crescents

研究标题:通过LN组织学病变的蛋白质组学分析,确定了纤维性新月体的炎症特征

摘要号:2097

Association of Renal Biopsy NIH Activity and Chronicity Scores with Clinical Outcomes in a Cohort of Patients with Lupus Nephritis

研究标题:在LN患者队列中,肾活检NIH活动性评分与慢性评分与临床结果的关系

摘要号:1636

Long-term Renal Survival of Patients with LN by Renal Response Status in the Toronto Lupus Cohort

研究标题:多伦多狼疮队列中,肾脏缓解情况对LN患者肾脏长期生存的影响

摘要号:0362

The Renal Activity Index for Lupus(RAIL)Identifies Active Renal Disease in SLE Patients and Its Longitudinal Score Associates with Renal Responses in Lupus Nephritis

研究标题:狼疮肾脏活动指数(RAIL)可用于识别SLE患者的活动性肾脏疾病,其纵向评分与LN的肾脏缓解情况相关

个体化治疗的理想如何照进现实,

生物标记物能否提供新思路?

摘要号:0977

Effect of Belimumab(BEL)on B-cells and Serological Biomarkers for SLE:Results of the Large Integrated Analysis BEL Summary of Lupus Efficacy(Be-SLE)

研究标题:贝利尤单抗治疗对SLE患者B细胞和血清学生物标志物的影响:大型疗效研究的汇总分析结果(Be-SLE)

摘要号:0640

Immune Cell Heterogeneity in Lupus Nephritis Kidneys and Its Relation to Histopathological Features

研究标题:LN肾脏免疫细胞的异质性,以及其与组织病理学特征之间的关系

摘要号:1655

Belimumab Disrupts Memory B-Cell Trafficking in Patients with Systemic Lupus Erythematosus

研究标题:贝利尤单抗可干扰SLE患者记忆B细胞的迁移

摘要号:2096

Role of Cell-Bound Complement Fragments as Biomarkers to Determine Disease Activity in Patients with Systemic Lupus Erythematosus

研究标题:与细胞结合的补体片段在评估SLE患者疾病活动中的作用

摘要号:0333

Autoantibody Trajectories Associate with Classification and Treatment Response in Lupus Nephritis

研究标题:自身抗体轨迹与LN分类及治疗反应相关

摘要号:0536

Change in Urinary Biomarkers at Three Months Predicts 1-year Treatment Response of Lupus Nephritis Better Than Proteinuria

研究标题:相较于蛋白尿,3个月时尿液生物标志物的变化对1年时LN治疗反应的预测效果更优

摘要号:0537

Neutrophil Extracellular Traps as a Biomarker to Predict Outcomes in Lupus Nephritis

研究标题:中性粒细胞细胞外陷阱(NETs)可作为预测LN预后的生物标志物

摘要号:0636

Serum Soluble Mediator Signatures of Lupus Nephritis Histological Features and Response to Treatment

研究标题:血清可溶性介质可反映LN组织学特征及治疗反应

摘要号:0650

The Association of Urinary C9 to CD59 Ratio with Tubulointerstitial Fibrosis in Lupus Nephritis

研究标题:尿C9/CD59的比值与LN肾小管间质纤维化的关系

摘要号:1135

Urine Proteomics Implicate Complement C3 and Factor I in Lupus Nephritis Patients with Interstitial Fibrosis and Tubular Atrophy

研究标题:尿液中补体C3和补体因子I(CFI)是LN伴间质纤维化和肾小管萎缩的潜在标志物

摘要号:1478

Urine ALCAM Is a Strong Predictor of Lupus Nephritis

研究标题:尿ALCAM是LN的有力预测因子

摘要号:0648

Pathogenic Anti-C1q Antibodies Potentiate Activation of the Classical Complement Pathway in a Subset of Lupus Nephritis Patients

研究标题:在部分LN患者中,致病性抗C1q抗体增强了经典补体通路的激活

摘要号:0327

SMART-SLE:Serology Monitoring and Repeat Testing in Systemic Lupus Erythematosus

研究标题:SMART-SLE:SLE患者的血清学监测和抗ds-DNA抗体的重复检测

摘要号:0978

Belimumab After Rituximab Targets IgA2 Anti-dsDNA Antibody Production and Shifts Repopulating B-cells Towards an Anergic Non-pathogenic Phenotype in Systemic Lupus Erythematosus

研究标题:在利妥昔单抗后使用贝利尤单抗治疗SLE,可靶向IgA2抗ds-DNA抗体的产生,并使重组B细胞向非致病、无变应性的表型转变

此文仅用于向医疗卫生专业人士提供科学信息,不代表平台立场。

awr报告详细解读(一文速览2022年ACR会议中狼疮领域的最新资讯)(3)

awr报告详细解读(一文速览2022年ACR会议中狼疮领域的最新资讯)(4)

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