什么检查能查出口腔hpv？口腔HPVDNA检测及一级
什么检查能查出口腔hpv？口腔HPVDNA检测及一级通过多个数据库合并分析，Gillision教授等建立了口咽癌发病风险模型。由此，口咽癌高危人群可被识别，进而可对他们进行二级预防。 二级预防：发现高危人群HPV感染同宫颈癌、肛管鳞癌、口咽癌等多种肿瘤发展有关。目前，HPV阳性口咽癌是美国发生率增长最快的肿瘤。一级预防：HPV疫苗接种，预防HPV感染。Gillison教授的研究团队通过一项纳入2627位美国青年人（接受至少1次HPV疫苗接种）的横断面调查，表明HPV疫苗接种确实能够降低口腔HPV感染。进而，如果让更多的人接种疫苗从而从中获益变得至为重要。
编译：肿瘤资讯
来源：肿瘤资讯
Maura L Gillison教授
MD Anderson Cancer Center
HPV感染同宫颈癌、肛管鳞癌、口咽癌等多种肿瘤发展有关。目前，HPV阳性口咽癌是美国发生率增长最快的肿瘤。
一级预防：HPV疫苗接种，预防HPV感染。
Gillison教授的研究团队通过一项纳入2627位美国青年人（接受至少1次HPV疫苗接种）的横断面调查，表明HPV疫苗接种确实能够降低口腔HPV感染。进而，如果让更多的人接种疫苗从而从中获益变得至为重要。
二级预防：发现高危人群
通过多个数据库合并分析，Gillision教授等建立了口咽癌发病风险模型。由此，口咽癌高危人群可被识别，进而可对他们进行二级预防。
三级预防：发现口咽癌中预后不良人群。
HPV阳性口咽癌患者预后显著好于HPV阴性患者。在阳性患者中，HPV持续感染患者预后明显差于HPV转阴患者。
Oral HPV DNA Detection and Primary Secondary and Tertiary Prevention
Maura L Gillison
MD Anderson Cancer Center
Human papilloma virus is associated with carcinoma of cervix anus oropharynx oral cavity and so on. Currently HPV-positive oropharyngeal cancer is the most rapidly rising cancer among US men.
Primary Prevention
In order to evaluate the impact of HPV vaccination on oral HPV infections among young adults in the US Maura et al. did a cross-sectional study including 2 627 men and women aged 18-33 years with self-reported HPV vaccination receipt > 1 dose. The results showed that HPV vaccines may prevent oral HPV infections that lead to cancer in men. Methods to improve vaccine uptake are warranted.
Secondary Prevention
Identifying individuals at high-risk of oropharyngeal cancer is of vital importance. Using database of Ohio State University case-series National Health and Nutrition Examination Survey and SEER an individualized 1-year absolute risk model for oropharyngeal cancer was developed. Individuals at high-risk of oropharyngeal cancer can be identified and therefore secondary prevention is possible.
Tertiary Prevention
HPV DNA is a biomarker for cancer persistence and progression. Patients with HPV positive at diagnosis had better 2-year overall survival than patients without HPV infections. In patients with HPV positive those with persistence HPV infections had poorer survival than patients with HPV cleared after treatment.
